| Item Type | Name |
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Concept
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Alkylating Agents
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Concept
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Antineoplastic Agents, Alkylating
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Academic Article
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Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
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Academic Article
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Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
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Academic Article
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O6-alkylguanine-DNA alkyltransferase in cutaneous T-cell lymphoma: implications for treatment with alkylating agents.
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Academic Article
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A phase II trial of oral temozolomide in patients with metastatic renal cell cancer.
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Academic Article
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Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
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Academic Article
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Temozolomide: realizing the promise and potential.
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Academic Article
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Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells.
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Academic Article
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Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
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Academic Article
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Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.
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Academic Article
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Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.
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Academic Article
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Cancer pharmacoethnicity: ethnic differences in susceptibility to the effects of chemotherapy.
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Academic Article
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Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.
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Academic Article
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Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.
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Academic Article
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Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.
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Academic Article
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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
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Academic Article
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Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
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Academic Article
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Repair of O-alkylpyrimidines in mammalian cells: a present consensus.
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Academic Article
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Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
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Academic Article
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Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents.
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Academic Article
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O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
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Academic Article
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Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study.
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Academic Article
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Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
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Academic Article
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Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies.
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Academic Article
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Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.
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Academic Article
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Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.
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Academic Article
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O6-benzylguanine-mediated enhancement of chemotherapy.
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Academic Article
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Multicenter phase II trial of temozolomide in mycosis fungoides/sezary syndrome: correlation with O6-methylguanine-DNA methyltransferase and mismatch repair proteins.
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Academic Article
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Mechanisms of resistance to the toxicity of cyclophosphamide.
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Academic Article
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Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
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Academic Article
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The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
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Academic Article
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Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients.
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Academic Article
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Hydroxylation and N-dechloroethylation of Ifosfamide and deuterated Ifosfamide by the human cytochrome p450s and their commonly occurring polymorphisms.
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